Hi,
it depends on so many things... but mainly on your "serial interface", it´s structure, it´s protocol, it´s timing behaviour, error handling, and so on.
But it also depends on your needs. There are many interfaces available, some are especialy designed for cameras. Some may suit your needs, some not.
Some examples:
* you could use an LVDS SERDES interface. No error handling, no frame sync, no bus system, no bidirectional data, ... just bare "data in --> data out"
* you could use ethernet. A bus system. Needs overhead for headers, error detection, collision control, block transfer means you neeed a buffer, bidirectional, ....
Each has it´s benefits and drawbacks. We don´t know your requirements, targets, preferences...
I recommend to do internet research. You are by far not the first one who does picture transport via serial interface. Thus there are several solutions for different requirements. No need to re invent the wheel. Gain from the experience of others.
Klaus