In my experiment , ADS and spectr-RF is the best choice ,
IF you work on LNA or Mixer , VCO that include inductor , that I think using ADS, others bolcks
like prescaler , VGA , AGC .. using spectre-RF
IF you want to F-domain ... ADS is better
time -domain ... Spectre-RF
ADS is largely used but it's cpu consumer.
MWO is well fashoned, rapidly growing, but it contain lot of basic limitations.
Genesys by Eagleware is a good choice on the cheaper range.
Harmonica (by Ansoft) is the concurrent of ADS, very accurate.