I think if you already have background knowledge of S parameter, LCR matching IP2, IP3, and specified modulation characteristic of your working standard, then it's possible to achieve your goal!!
Then next you may go following steps:
1. Do calculations of system cascaded over RF parameters, NF/IP2/IP3/P1dB/ACPR.... for one week
2. Take PA Evaluation board to do the testing over all performance, and try to tune the output matching.
3. Take system EVB to go parameter checking, and try to relating this to spreadsheet calculation for 1st week.
Good luck!