The simulation skill apply to any circuit:
You can use transient simulation to catch some non-linear problem: for example, the output swing of the OTA, the non-linearity of the ON-resistance. However, be careful on the result: Because, device mismatching is not included for the transient simulation. Some side calculation is required for this one.
Another one is: the noise effect is not included in the transient simulation. Notes: in the latest cadence tool, the vendor try to include it, using some random number generator.