There is no answer to that. There is nothing like the ideal simulator.
For RFIC design, for example, you might want to use a 2D, 2.5D AND 3D simulator for specific details in your circuit.
Each has its unique advantages and disadvantages which are very specific to the application.
If you have to make a comparison then stick to apples versus apples. For example compare M*MENTUM versus S*NNET OR C/S/T-MW-STUDIO versus HF/SS