integartion is a solution for you. how about the amplitude of you current? If the current is smaller than the leakage current of your circuit. it is impossible for you to sense it.
CMOS is very noisy, the best amplifier we can find in the market has around several nV/sqrHz input refer noise and they use JFET as input stage I think, how to use CMOS to sense Pico-Ampere current? Any paper, book?
Picoamp measurements are done routinely for patch-clamp research of the currents through the cell wall. Although, I don't know what's the circuit. Thanks a lot for the link. I need to measure whopping nanoamps.