I guess MWO is much more user friendly and you could quickly adapt easily. But still, it depends on the type of applications you're going to use them for...
M/W/O and E/a/g/l/e/w/a/r/e are both easy to use. M/W/O has the better system and E/M/ simulator. E/a/g/l/e/w/a/r/e has the better filter synthesizer (and PLL, too). @/D/S is the hardest to use and its circuit synthesizers are from the dark ages. If you are just getting started, try the student version of A/n/s/o/f/t S/e/r/e/n/a/d/e. Its free.
generally speaking ads and mwo is better than genesys but of course, you pay a few times more than you pay for genesys. If you do not need these for high frequency, i.e., above 10 GHz, you can use genesys at a fraction of the ads price.
By the way, Genesys is catching up very fast. Soon it will match the other two but with a lower price. Also at RF frequency, it is a good software to start with.
Gene$y$ is a combination of misc tools.
MW0 is general tools,
AD$ is a complex and delux platform
it has been integrated into $PECTA RF
$erenade is a good circuit simulater.