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M/W/O and E/a/g/l/e/w/a/r/e are both easy to use. M/W/O has the better system and E/M/ simulator. E/a/g/l/e/w/a/r/e has the better filter synthesizer (and PLL, too). @/D/S is the hardest to use and its circuit synthesizers are from the dark ages. If you are just getting started, try the student version of A/n/s/o/f/t S/e/r/e/n/a/d/e. Its free.
generally speaking ads and mwo is better than genesys but of course, you pay a few times more than you pay for genesys. If you do not need these for high frequency, i.e., above 10 GHz, you can use genesys at a fraction of the ads price.