if analog, it depond on you supply voltage.
this is to say, if you use high voltage device(i/o device), there is no more difference. but if you core device(1.2v for .13, 1.8v for .18), you must pay attention to the change of the supply voltage.
Hell yeah scaling.....there will effect a lot of things..........
Roughly said....
Pay attention to secondary effect, and the standby power of your device...
u r designing analog right...so the changes will effect the capacitance value of your devices, sometimes it will make your circuit better due to the less capacitance value...but that is quite simple for digital in analog sometime we need the large capacitance to make a switch