Deep trench isolation on SOI material completely isolates
transistors. STI is Shallow, not complete.
Hot swap means you want to plug something in with
power already on. This will also include live signals and
loads. They may be applied in almost any order. Pins
pulled hard below ground (Psub) or above VDD (Nwell)
can trigger an SCR path. The manufacturer would prefer
to not design for every pin-pin combo (even if possible)
but to simply say "don't do that, or it's your problem".
That's "proper supply and signal sequencing", which is
a luxury somebody else has to provide. For applications
that must withstand broader challenges, you address
isolation with better (for that) technology and maybe
some circuit tricks like body-blocking / body-pulling
circuitry to keep the diode conduction paths under
control as well, since now you'd have isolated device
bodies to play with. '
'
You -can- make a chip latchup immune without SOI.
Thin epi, degenerately doped handle, guardrings
instead of sparse tap contacts, and you're about there
as long as you don't miss a spot. But some jobs just
can't be done with a bazillion diodes every which way,
just waiting to put in their two cents. Then it's SOI of
some sort.