Don't think B2B diode use for clamp ESD because the trace length to TVS clamp diode is too long, and impedance will come high to surge voltage. To protect ESD, surge voltage, TVS/ MOV will place close to where input place, the shortest trace to Power GND for better discharge current.
For price or require lower capacitance, some TVS use multiple B2B diode with 01 TVS clamp diode like image in#11. But this solution make higher clamp voltage as expected.
The rule to select TVS is the stand off voltage, it is same or higher the maximum dc voltage which apply on that net.
For better signal TVS should care it structure (or full detail info), that is why supplier drawn.