Not for high reliability with digital, for bargain basement designs maybe, but even those these days with Signal Integrity/EMC issues at the forefront are at least 4 layers (and that is the absolute minimum). With the devices specified I would suspect that the footprints are not conductive to a double sided design. Any impedance controlled would be almost impossible if it is required (try routing a 50 ohm line on double sided...) as would proper control of signal returns and power distribution.I often use two layer boards for high reliability industrial circuits.
If the OP wants a 2 Layer PCB, i let him do so.
I would love to disagree with KlausST (and for a lot of designs do) but 2 layers can be made to work, did a test board for a GPS module (with RF) that had to be 2 layers for cost reasons and it works.....But it was a pain and there were lots of compromises in the layout (GND and power distribution being 2) and the 50ohm RF tracks were a tad wide....
But I still say with todays RF polluted environment, noise and EMC requirements 4 layers should be a minimum, and many more are often required.
I do life/mission critical designs and NOT one of them would be 2 layers, they are/would be 4 or more layers.
I think there is a lot to learn here. Can you give us a few tips of what kind of things go wrong with increased production.
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