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Lithium-Ion 1S 3.7v or 2S 7.4v

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networkit

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I am working on a video transmitter with operating input voltages between 6v-12v. The unit draws 220mA and has an integrated 5V out rail that I will pull an additional @380mA. My main concern is that the unit stays powered for as long as possible but due to my size constraints it can only accommodate 1000mAh - 1100mAh lithium-ion pack. My question is, which would be best suited for this project, a single cell (3.7v with booster) or a 2 cell (7.4v) li-ion pack?

Thanks!
 

Anyone have any input on this?
 

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