Keysight ADS can be used for PCB designs but it's not very user friendly.
The best layout for pure RF designs is Cadence Allegro RF Option in my opinion.It's working seamlessly bilateral between ADS and Allegro.
Looks interesting, bet it costs though... I do it manually or via DXF transfers from whatever the RF guys we are working for plays on. Luckily I only tend to do approx 1 or 2 microwave boards a year (I try to avoid them as I have just spent 5 weeks on one!!!! Digital and RF all crammed in, great fun).
If I used Allegro and did more of them that add on would be on my wish list...