Hi,
If you are referring to sense amplifier in SRAM block used for data reading...
You need to design the transistors with certain W and L, so in Monte-Carlo analysis the input offset voltage of your sense amp will remain under a specified value. Maybe read some material on mismatch, pelgrom's plots and pelgrom's coefficients.
Offset voltage usually has normal distribution. You are basically tuning its mean value and standard deviation by W and L of the transistors.
Sense amps are usually very simple and symmetrical, so it should not be too much work
Good luck with your design