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How compensate amplifier input current?

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Astrid

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Trying to figure out a way to clear the current input FET amplifier (tens of pA).
Before entering the amplifier have a protective resistor 100k on which the current 10Pa an error occurs 1uV.
I watched how the proffesional do it.
Output short circuits prior to resistance and null current with injected small current.
I found, see picture but I did not understand how it works.
Precisely how MCU determines how to set the DAC?
Nullum the input current FET transistor
CC.png
 

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