This is hard question, but your question is incomplete and dont have lots of parameters. Very often for RF experiments with measurements must be done.
1. What antenne ?
2. Surounding and blocking objects ? Material of this objects ?
3. TX RX are completely isolated from other RF sources ? We are in NY city streets or somewhere on open seas ?
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In cities and in building higher frequencies, on open lower. Higher frequencies have better penetration throught objects then lower frequencies. This is just my opinion, maybe other members have different opinion then mine.