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Means you have the amplifier as component with four external resistors defining the gain? You might use current sources to inject an offset current to the inputs, e.g. a differential pair.
Yes it does. Even more problematic might be reduced CMMR in case of asymmetrical resistor circuits. A possible option is fixed offset compensation resistor pair, considered in the gain calculation, drive by an adjustable voltage source (e.g. a pot with resistance low compared to compensation resistors).I have tried connecting a pot to the negative input and in simulation this affects the gain.