Hello
to detect 1uV input voltage change will need very high gain circuit which doesn't have any offset voltage, for this case it is hard even to use CMOS Differential amplifier which exhibit an input offset voltage, any way by the meaning of very high voltage gain you can not use simple differential amplifier rather thanhigh performance op-amp.
it seem from your question that you are just interest in the detection value, mean you are looking to work if I am not wrong with open loop condition, if it is right then you have to search for comparator design circuit which has a slight different from general Op-amp specially if you take the transient response in your consideration