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Sometimes, a fast transient on any of the I/O lines (for instance, from ESD) will trigger it.
A device which has suffered that fate will remain latched up until power is turned off. Therefore....If left unattended for extended periods of time, the device can self destruct.
A significant substrate current can trigger latchup, such as an overvoltage (above the power supply voltage) or undervoltage (voltage below ground) on one of the inputs.
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