EM Simulation cannot involve into Circuit Simulation with SPICE parameters or s-parameters of the devices.
The layout is simulated first without active and passive elements then this is re-simulated with s-parameters in circuit simulation set-up.
You can add SPICE and/or s-parameters of the components in this set-up.SP,AC,DC,HB,TR etc simulations can be done in this schematic set-up
Refer to Co-Simulation of Keysight ADS Manuals..
Note : A new RFPRO Option of ADS 2019 has a capability to simulate s-parameters only with active and passive components and their small signal models.