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If you (or your company) own the software, and it is eda-ema (cadence package) then call service. Andrew in tech support is very helpful. He has helped me many times and can usually get thing solved. I have had that problem too. BUT, have not called and asked to fix that problem. I think it is because of other things installed and running (in the background/Windows) while PSpice is running, or an install that is not good any more. Make sure you get the latest version of the software.
I hope that helps!