Maybe not remove it. It depends why it was put there in the first instance. If the design requires a short delay after power-up before releasing reset, it may be there to provide it. MCLR will rise slower than +5 because of the time it takes to charge the capacitor through R15. If the delay isn't needed you can probably not fit the capacitor at all, otherwise add a resistor (~1K) between the PIC and R15/C4 and connect 'RST' directly to PIC pin 1. The new resistor will isolate the capacitor from the programming voltage.
Brian.