Re: MixedSignal layout issue
Avoid the stupid error to simulate a power supply net somewhere in the middle of the project!
There are sucessful SOC matching your components. But start before doing any scheduling and circuit partioning of a supply analysis.
Model the board components, the package, the internal decoupling, the internal impedance, the internal noise sources, the receivers, the interface between quiet and noisy, substrate separation and connections, ...
This simulation formation provide you enough guidelines for the SOC project.