Hi there,
So to start, all your R's should be in the same orientation. No rotations. Also, they should be the same Width. If you can make them all segments of each other that helps as well. As for C's, same orientation as well. Also, maybe you can make multiplies. As for transistors, is this high speed or low speed accurate. If your high speed, things are normally small and cross quads/common cent will add to much cap and kill you. Here since things are small its best to put side by side. If its slow, follow normal techniques like common cent/cross quads.
Hope is helps,
JGK