In the development of DAQ system is necessary a calibration?

[kitepassion]

I am planning to build a DAQ system to make some voltage measurement in the lab. My aim is to measure the Vth of a Mosfet.
I am developing a DAQ system made by an FPGA and an ADC. Is it necessary to calibrate the system? Can I trust just the datasheet? .
I want to put an instrumentation amplifier at the input but it is not necessary. Now the analog inputs are straight in the ADC.

Thank you

 

[barry]

You can believe the datasheet, but can you believe your design? You most certainly need to do some testing to verify that your circuit is working; why wouldn't you? Are you proposing just throwing some components on a PCB and hope that they are all connected properly?

You make no mention of your required accuracy and resolution.