The parasitics introduced by the I/O pads detune your LNA from the conjugate of Γ-optimum.
In your simulation you have to tune your LNA for best NF with these pads interconnected to your circuit.
There is not olny detuning but the PAD-IO model add substrate resistive loos to the input circuit. If you can select a PAD with metal shield under PAD metal it improve your NF.
when u design LNA , u always design the input matching network for Γ optimum
which mean that it is the best input impedance for the noise matching this gives you the minimum noise figure
but u must take into account the model of the pad , the bond wire , and the package , and modify ur matching network with the new elements that have been added
Make sure you are not using I/O pads for digital signals and bias from your design kit library. They contain ESD diodes and resistors that will kill your NF.
i think most of the design kits right now include pads for RF and analog circuits if the kit doesn't include these pads , so u have to create the Pads by ureself so u can control the capacitance of these pads