If this offset is from a common-mode input offset and
you need to work down to DC then an instrumentation
amplifier front end might be the ticket. If you are only
interested in AC then high-pass filtering is cheaper.
The details are not clear and you need to consider
what you want and what you must reject from the
input. For example is the DC offset internal or external,
fixed or time-varying, what is the highest "junk" and
the lowest "valued" input frequency, etc.