design for corner cases - how to decide the optimum margin?

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rama_bing

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design for corner cases

i am new to analog design. i want to design a circuit which works at all corners. i am designing circuit with some margin ( design amplifier for 60db gain, if the spec is 50dB). Is there any way to decide the optimum margin for a spec based on the technology and circuit topology.
thanks
 

Re: design for corner cases

Is there any mistake in my question?
 

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