Maybe not a good idea to share the same crystal between two ICs, try disconnecting the OSC output from U6 or you have two conflicting outputs connected together. Ideally, use two crystals.
What does R54 do? The -INT pin is an open-drain output from U6 and seems not to be used anyway. I would remove R54 and make R53 100K if you are worried about leaving the pin floating.
I'm not familiar with the STM32L422CBT6 but I would consider adding a diode across R33 to speed up discharge of C19 when power is removed.
Brian.