There are lots of issues in IC layout and you have to consider them.So it is hard to explain all of them. but important ones can be
1) If you are designing differential LNA symmetry is really important. So for example you apply techniques like Common-Centriod for your transistors in order to avoid post fabrication mismatches. There are significant matching errors when using transistors, or resistors, or capacitors, if common-centroid layout isn't used. There are always more-or-less linear gradients across a die.
2) In high frequencies even a short connection between two blocks can be a parasitic (jLw) so you have to minimize them as much as you can.
3) EM simulation MUST be done in order to optimize circuit. You will observe parasitic effects (like inductor and capacitor
self resonance and parasitic resistances) and also Coupling between two inductors.
So for example if two transistors are close to each other and effecting each other, you may rotate one (Probably you will have lines not inductors with turns, since your frequency is high)
4) You have to do power distribution. It means that you cannot connect one component from only one corner or part to another one and
you should distribute your signal.
and many other things ...