Altium Designer does not support the MSP430 directly, but maybe the TSK165 is 'compatible' with it (it is based on a 16-bit RISC). The TSK3000 is a 32-bit RISC processor.
For soft designs, independent from the FPGA used, you are limited to the devices like TSK51, TSK52, TSK80, TSK165, TSK3000 (these are the 8051/8052/Z80/165x/3000 equivalents).
If you are using a specific FPGA then you can also build software for Actel COREMP7 (ARM), Altera NIOS2, Xilinx MICROBLAZE, Xilinx POWERPC (additional licenses of the FPGA manufacturer may be needed I think, unless the processor is already build in, like the PowerPC for Virtex FPGA's).