The difference between two-wire and three-wire transmitter is that with the three-wire transmitter, some current is flowing through additional terminals, in case of XTR110/111 an additional ground terminal. The device isn't designed to be operated in two-wire mode, although it would be possible with an additional amplifier circuit, I guess. But you would normally refer to a different XTRxxx chip in this case.
The XTR110/111 can be operated with a two-wire input circuit if it has a grounded current shunt and you have access to the ground node additionally. I believe it's possible with most PLC input modules, e.g. it would work with Simatic S7 analog inputs. The XTR110/111 ground current is small according to datasheet, e.g. 0.5 mA.