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In Uplink(user to basestation): increase of users will have different offsets to eachother as well as propagate via different channels. These will greatly reduce the orthogonality between codes allocated for each user so the interference.
In Downlink (basestation to user): The increment of users will increase the multiuser intereference due to the non-ideal orthogonality of codes
Increasing number of users will increase the effect of multiuser interference because in the same bandwidth, correlation of spreading codes are increasing. You may reduce the effect of multiuser interference by using multiuser detection method which requires the knowledge of all users. The more information you have, the more efficient system you will have.
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