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Hi Majero,
The main mirror M3 and M2 need to be sized according to the matching you need between your input and output current. With that size you can look at the Vdsat you get, if that is not enough you can increase the size more. Once you have sized that sufficienctly, you can size M1 and M4 as large devices so that they have a minimum vdsat. The only limiting factor on M1 and M4 would be the size you are willing to spend. Now you have the need to size M5 with whatever current you decide to bias it with so that its Vgs = Vgs(M4)+Vdsat(M3)