Differential are previously used for precision circuits as it requires more resource compared with single ended. it works by sending a 90 degree phase shifted waves in 2 different lines with respect to a common reference. So when a EMR is applied it will affect both the wires so it will become a common mode signal so it is automatically filtered in amp in the front stage of the receiver, so it is used nowadays in high frequency systems as the effect of interference is more at high frequency operation.