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Voltage Sense Amplifier

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Astrid

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Someone tell me what is behind the scheme in Figure?
It is Voltage Sense Amplifier, for measuring 1mVpp 1MHz with DC offset 1V) over 2m coaxial cable.
The problem is non-zero potential of the coaxial shield (say 100uV).
How to convert the voltage to "single end" , is required diferencial amplifier or at such small differences against ground?
Thanks you
Amplifier.jpg
 

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