Do you mean driving the LCD panel directly with the MCU, or using an existing analogue (RGB, SVGA, HD15) input?
If you mean driving the bare panel, then you will have a lot of work to do. Starting with identifying the exact panel and finding its datasheet. It might just be possible, but unless you have a very powerful MCU (what do you have in mind?), or want to use an FPGA or dedicated display chipset for the interface, it's probably not realistic.
If you want to drive the analogue RGB input, that's different, although you still have a lot of work sorting out the timing and running a framebuffer. And using 3 DAC's unless you just want 8-bit colour.
I've seen a few notes about doing this, but can't find them at the moment. Can you give more details of how you want to do this?
FoxyRick.