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As papyaki said you can use any spice simulator, at duncanamps there is explained how to use the models in /P*s*pice. There are different models some for berkley spice and some for the /O/*rcad. If you run into problems I try to help, if I remember how I did it
In circuitmaker there already exists some tube schematics and models. Check there first.
If youl ike you can check for more info here: