While your mismatch distribution may be worse, your signal
range should be substantially better (not knowing what you
mean by "high" voltage - I've worked in processes where the
high voltage FET was only 3.6V, and others where the low
voltage FETs were 40V). So your net SNR may be OK, and
determining this (requirements vs capabilities) is a good
place to begin.
If your "natural" capability is going to produce unacceptable
offset voltage then you will have to take circuit measures
such as trimming, chopping, etc. These have their costs and
some systems can't tolerate chopper noise or non-continuous-time
operation.