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Not sure about VB6 but in VC6 one uses the DeviceIOCTL function calls to set up endpoints for USB comms. Each device must be enumerated and run in its own thread. USB can be complex due to the implementation in OS!
At the pripheral side you need a usb controller such as Cypress ones or other options
And You need a driver either developed by the chip manufacturer or by you
And the final thing that you need is a software developement library that is able to be used in VB6
The easiest way is to use FTDI usb to serial converter module or chip....
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