Strictly spoken, a PCB causes no noise. Apparentling, you're referring to the role of PCB design in propagation of interferences from digital to analog circuit parts.
Obviously, you can't analyze it, without knowing which interference sources and which pathes for their propagation exist in your design. E.g. interfering currents propagating through the ground plane, power supply decoupling and filtering, capacitive and inductive coupling. Without knowing about possible pathes, e.g. Cadence signal integrity tools won't help much. Cadence sales will possibly tell different, but it's mainly a matter of experience, empirical tests and measurement.