I'm looking for what would be a good clock frequency for a general purpose FPGA design. The FPGA currently preforms some basic counting and sequencing for industrial control functions but could expand to future field applications where necessary. Currently it uses a 37.5Mhz clock from a DSP that resides on the same PCB, but I'd like to add one more for standalone operations.
That depends.
What is the fastest frequency you intend to run future designs at?
If it's a large FPGA, with many registers I'd pick a much faster clock - In the range of 150 Mhz.
Not really.
You do need to take special care of high speed signals however.
It's the rise/fall times you should look at when analyzing signal integrity issuse - not the direct frequency.
If you worry about radiation, you can route the signal as a microstrip (not a stripline).
Use proper terminations and keep the trace as short as possible.