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i think it must be between semi-custom to full-custom design. Both of them are custom designs. Full-custom layout designs came from scratch. Even cell libraries are made in full-custom.
Custom Design --- This means the complete physical design layout is done manually. Even the cells or libraries are done manually. This method is mainly used if NRE cost comes out to be very low.
Semi-custom-- Here, some part of the layout is done by EDA tool viz. ASTRO,Soc Encounter etc. and to get the optimized results we do it manually. The vendor gives the std. cells and libraries if the tech. needed for the design. Designer needs to be very proficient with the tool and it's good if he has good understanding of algorithm running in the tool
FULL CUSTOM allows you to freely draw the polygons in the different layers in order to get the desired result. Freely actually means not limited by a pre-designed cell, but yes you must follow the design rules for the process you're working on...
SEMI_CUSTOM: Is the design based on pre-designed cell (actually P-cells, cells with parameters you can change) for the different components available in the fabrication process. The P-cells are all included in what is called the Standard Components Library and you must design by using the components from there. The only freedom degree you have is to modify the component size or other features by changing the component parameters... In the real world almost only the semi custom is used...
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