I want to use data from MATLAB as an input vector for my Spectre simulations.
In the past, I created a seperate pwlf source for each bit of the bus.
This worked well, for small small bus widths .
You could perhaps use an ideal DAC mechanism in MATLAB to transfer your bus into an analog signal, feed it to Spectre's ADE and re-convert it there with an ideal (behavorial, {A,V}HDL) ADC back into the bus format.
I don't know, however, if the accuracy is sufficient.