I am never seen this kind of constraints.
To avoid rotation or flip possibility for std cell, you could modify the lef file which indicate with transformation are allowed "X" "Y" & "R90", which mean mirror versus x axis or y axis, and rotation by 90degres, but this will be apply for the type of cell and not a specific instance.
Generally, I placed by script the cell, I want to see at the "perfect" place.