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Not particularly. More interesting parameters are source impedance and signal bandwidth. Matched 50 ohm signal transmission achieves a flat frequency characteristic and resistive load up to GHz frequencies. It's sometimes used at low MHz frequencies, e.g. because instruments are provided with 50 ohm matching, but it's not general necessary. The most serious problem is, that your circuit must be able to drive 50 ohm. if it's not designed for 50 ohm matching , it most likely won't. Also in high frequency circuits, you can't simply attach a 50 ohm load to a circuit node without affecting circuit operation. So probes with resistive divider (500 to 5000 input resistance) or active probes with built-in amplifier are used to probe high frequency signals (almost) undisturbed.so if im going to measure very low AC voltage signal, its more approriate to use a 50 ohm terminated BNC