Hi,
My first question is: What do you want to do with the amplified signal?
--> If you just want to measure it's amplitude: try if a lock in amplifier can be used.
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The next question is: Where does the signal come from, and all the specification for the signal and your application.
Source impedance? Is it a fixed frequency? Do you actively generate this frequency? What other frequencies exist, that need not to be amplified (suppressed)?
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The rest is guessing:
If you really need the analog waveform, then you need a true amplifier.
Whether to use a single Opamp or two stages depend on your needs.
I imagine you want it to amplify to get a signal of about 2Vpp, then you need a gain of about 1 million.
Oh yes, that's huge.. A single stage won't work..
Klaus