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i think it all depends on the way the two signals are , like u want the switching MOSTs be hard switched so u need a large square wave for that (i.e. LO signal),so a small signal of the RF wont switch the pairs which wont give a good mixing and a very bad noise figure.
while usually u need a gain to the RF signal (usually small as it arrives weak to the receiver so actually u depend on the high gain to deleiver a larger signal , while if the LO signal is put on the RF it will most probably saturate the mixer)
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