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The relationship between the drawing layer and recticle figure is important:
use ptype substract as an example:
drawing layer recticle clear or dark in recticle
nwell nwell clear...
if you want to do full custom layout design, you need:
cadence corporation's software virtuoso is better than others.
if you want to do place& route , you need :
1.synopsys's Astro
2.cadence's socencounter
are also good tool
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